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Sex steroids Sex dimorphism in the circadian system arises from the diverse effects of sex hormones on physiology and behavior, which are regulated by the hypothalamic-pituitary-gonadal (HPG) axis, a central mechanism that governs reproductive processes and broader endocrine interactions 70
Despite demonstrating biological activity and a favorable safety profile, AOD9604 has not achieved regulatory approval as an obesity therapeutic
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It was suggested, therefore, that the paralysis was of neural origin
