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doi: 10.1038/nrn3856 91 SharmaG
In in vitro studies, transient exposure of human esophageal squamous epithelial cells to acidic bile salt solution did not result in epithelial cell necrosis, but rather promoted cellular secretion of IL-8 and IL-1, which induced recruitment of lymphocytes and neutrophils further leading to epithelial cell necrosis (66)
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