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GI side effects (nausea, vomiting, diarrhoea) are the most common reason for discontinuation Rheumatologists managing psoriatic arthritis patients with obesity should co-manage with dermatologists or endocrinologists

Despite their significant clinical potential, they are associated with certain limitations, including suboptimal pharmacokinetics and patient adherence challenges, necessitating the development of advanced drug delivery systems to optimize efficacy and improve compliance

Because GLP-1 cannot be deleted specifically without affecting the other products of the proglucagon gene including glucagon, attention has focused on the GLP-1 receptor gene which can be deleted independent of the glucagon receptor

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