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Interestingly, and in contrast to colesevelam, liraglutide increased reabsorption of bile acids [assessed by 75-selenium homocholic acid taurine test (SeHCAT)] and decreased bile acid synthesis (assessed by circulating C4), possibly via a liraglutide-induced increase in FGF-19 secretion from enterocytes, thus rectifying core pathophysiological features of bile acid diarrhea
These genes control mitochondrial iron, tRNA transport, and ubiquitination (62)
Note on humans: No completed trial has shown clinical benefit
doi: 10.1096/fj.201901080R 85 HeHXuHXuJZhaoHLinQZhouYet al
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