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In addition, when DPP4i is combined with insulin secretin or insulin itself, DPP4i provides a complementary effect due to its inhibition of glucagon secretion and reduction in hepatic glucose production, which also means that a beneficial effect on glucose control can be achieved even with reduced cell function [94]

Expert Insights Most people with T2D will eventually need combined therapy, and the GLP1-RAs/SGLT2is combination may prove more effective in some groups of patients

1 Participants were randomly assigned to either Wegovy 2.4 mg or a placebo, alongside lifestyle support

At list prices of $13,000 or more annuallyand with millions of potential beneficiariesspending could be quite high initially