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Based on a previous methodology (Zhang et al., 2020), animals were randomized into six experimental cohorts (n = 8 each): a healthy Control, a DSS-only Model, a positive control group receiving Sulfasalazine (SASP, 200 mg/kg via gavage), and three ATT-I (Macklin, A860603, China) intervention groups administered intraperitoneally at dosages of 10, 20, and 40 mg/kg (saline containing 0.1% DMSO) from day 0 to day 10 once every day

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