Lysine-generated inflammatory NO is controlled, whereas with excessive dietary arginine, inflammatory NO reacts with superoxide to form peroxynitrite, which interferes with energy generation, damages DNA and is found with many (if not all) serious diseases.51 Recalling that lysine is a ketogenic amino acid, it is also noteworthy that one function of ketones is to inhibit arginase
64 The mechanism of DNA methylation-induced senescence is strongly linked to protein homeostasis loss, mitochondrial dysfunction, stem cell failure, and immune aging
"Jacobini" makes another appearance as the star of the opera Faust , appearing in costume as Mephistopheles (page 53, frame 6) and then as the name on the poster in Bianca Castafiore's dressing room (page 54, frame 13)
doi: 10.1161/circresaha.114.301958 17 FriedmanSLNeuschwander-TetriBARinellaMSanyalAJ