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The biosynthesis of SELENOP, involving the incorporation of multiple Sec moieties, is modulated by two SECIS elements in the 3 UTR region of SELENOP mRNA, reviewed by Shetty and Copeland (2018a)

This histamine-release response responds well to intravenous antihistamines and to slowing or stopping the infusion

It is perhaps interesting to note, given the association of paracetamol induced drug-induced liver injury (DILI) hepatotoxicity and mitochondrial toxicity18,19 that CYP2E1 is located not only in the endoplasmic reticulum but also within mitochondria

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