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"I cannot say we had a clear vision of where we were going, but we had started with the notion that we could block carcinogenesis if we could isolate these substances," Talalay told Johns Hopkins Magazine in 2008

Paradoxically, steroids can have a feminizing effect in males, including shriveled testicles and enlarged breast tissue

510 Nedosiran, another RNAi drug developed by Dicerna Pharmaceuticals that targets LDHA, is currently being evaluated for its efficacy in reducing oxalate production