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This bypass of the traditional Hayflick limit suggests a profound impact on cellular replicative lifespan

The ominous octet (Defronzo model) includes: decreased muscle glucose uptake, increased hepatic glucose output, impaired incretin effect, alpha-cell hyperglucagonemia, increased renal glucose reabsorption (SGLT-2 upregulation), increased lipolysis (adipose), decreased central satiety signaling, and decreased beta-cell insulin secretion

Disease Management and Clinical Outcomes , 1(4), 136-141

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