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This discouragement often leads to premature discontinuation, as evidenced by real-world data showing that 75% of patients without meaningful early weight loss will not achieve clinically significant results after six months of behavioral therapy alone

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If a patient simply stops taking the medication without learning healthy cognitive coping mechanisms through psychological therapy and leaning on community support, the underlying emotional triggers will remain waiting to resurface

This difference explains why the trial will likely be terminated early, and a more objective background risk estimation needs to be performed (if available) compared to heterogeneous prevalence studies