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60 Similarly, BCAT1, which is highly expressed in breast cancer cells, promotes mitochondrial production and function by activating the mTOR signaling pathway and ultimately promotes breast cancer cell growth

However, the synergistic effects of metformin and GLP-1 RA on renal function remain unclear in clinical research

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The FDA-approved prescribing information for tirzepatide includes a warning about acute pancreatitis, consistent with labeling for other GLP-1 receptor agonists, but this reflects precautionary monitoring rather than confirmed causation