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1 Introduction The rising global prevalence of hypertension, diabetes, and obesity has precipitated a parallel increase in kidney disease incidence, imposing a significant public health burden (Jing et al., 2024)

Given that proline and hydroxyproline together account for approximately one-third of collagens amino acid content, increased proline biosynthesis is now considered a key metabolic driver of fibrotic remodeling [13,14,15,16]

Cortisol can raise appetite by heightening the brain's reward response and by working against satiety signals such as GLP-1, the hormone that helps you feel full

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