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These meds are often less expensive than semaglutide, and a 2025 trial published in the New England Journal of Medicine that compared both medications found that tirzepatide was more effective for weight losshelping participants drop up to 25% of their body weight over the course of the 72-week study

Over the course of several weeks, as you continue with your treatment, these effects become more pronounced, helping you feel fuller for longer periods and reducing overall calorie consumption