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NGF / TrkA NGF (Nerve Growth Factor) is critical for basal forebrain cholinergic neurons involved in memory

10.1016/j.addr.2018.04.008 [DOI] [PMC free article] [PubMed] [Google Scholar] Schiller H

Expression of EPAC1/2 is upregulated by PI3K-AKT signaling in melanocytes and EPAC2 activity is required for the growth of transformed melanocytes To test whether EPAC signaling is activated and plays a role during malignant transformation of melanocytes, we transformed cultured neonatal human melanocytes (NHM) with lentiviruses for oncogenic BRAF (BRAF V600E ) and/or short hairpin RNA (shRNA) for PTEN (phosphatase and tensin homolog)

Pigmentation and inflammation are brought on by these variables