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doi: 10.1056/NEJMc1712572 35 Aristizbal-ColoradoDOcampo-PosadaMRivera-MartnezWACorredor-RengifoDRico-FontalvoJGmez-MesaJEet al

Recent FDA approvals have expanded the indication for semaglutide to include the reduction of major adverse cardiovascular events (MACE), such as heart attack, stroke, and cardiovascular death, in adults with established cardiovascular disease and obesity

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This meant GLP-1 would need to be given in high doses if it was to have any therapeutic potential