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Studies indicate that in mild OA patients, using ferroptosis inhibitors like Ferrostatin-1 (Fer-1) can significantly upregulate GPX4 and SLC7A11 expression while downregulating ACSL4 expression, suggesting the potential for early intervention with these inhibitors (Y

Specifically, ALA enhances GSH, a natural antioxidant involved in antioxidant protection, nutrient metabolism, and the regulation of cellular processes