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Without adequate SAMe production from the methylation cycle, the brain cannot efficiently synthesize neurotransmitters like dopamine, serotonin, and norepinephrine, leading to mood disturbances, anxiety, and profound cognitive fatigue

Similarly, alcohol and caffeine consumption close to bedtime may irritate the stomach lining or trigger acid reflux symptoms

For patients in New Orleans and South Louisiana, where the heat discourages activity and the food culture is rich and calorie-dense, the metabolic challenge is real

For example, cagrilintide can reduce the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP), two potent orexigenic peptides, and increase the expression of proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART), two anorexigenic peptides, in the arcuate nucleus of the hypothalamus (Roth et al., 2018, Physiol Behav)