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Epigenetic Interplay of Signal Transduction Regulation The connection between signal transduction defects and ASD pathology has opened up the treatment possibility of pharmacologically targeting these pathways, including PI3K/AKT/mTOR (mTOR), Wnt/-catenin (WNT), Notch, brain-derived neurotrophic factor (BDNF)-TrkB, sonic hedgehog, retinoic acid, bone morphogenetic protein (BMP), and MAPK/ERK pathways