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The conservative approach involves cycling use (4-12 weeks on, 4-6 weeks off) to prevent potential receptor downregulation and maintain effectiveness

Comment: A commenter requested that CMS reassign CPT code 0640T to APC 5722 (Level 2 Diagnostic Tests and Related Services), which had a proposed payment rate of approximately $220 for CY 2026, based on a crosswalk to CPT code 0598T (Noncontact real-time fluorescence wound imaging, for bacterial presence, location, and load, per session

The standard approach often begins with a low dose of semaglutide, commonly 0.25 mg weekly for the first four weeks, which serves primarily as an initiation dose to allow physiological adaptation rather than providing significant therapeutic effect