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Description

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The sulfur atoms in persulfides participate in the energy metabolism in mitochondria serving as electron donors as well as electron acceptors and are mostly likely to be excreted as thiosulfate eventually

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In a manner similar to that observed in liver, the accumulation of intramyocellular DAG impairs insulin signaling and muscle glucose uptake by activating PKC (muscle-type nPKC) [112,113], which elicits the phosphorylation of IRS-1 at Ser1101 and blocks the insulin-stimulated phosphorylation of IRS-1 [114,115]

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