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The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability

Polymeric nanomaterials such as poly(lactic acid) or polylactide-co-glycolide (PLGA) have ester bonds which undergo hydrolysis at the lower pH to release the cargoes, while co-block polymers containing boronic acid moieties possess altered solubility in acidic environment

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