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Early human data and practitioner-reported experience have linked this mechanism to potential downstream effects on body composition, lean muscle, and recovery, though evidence for hard clinical outcomes in healthy adults remains mixed and limited, and these associations should not be interpreted as established effects

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( h-i ) KG abundance in cells treated with the IDH1 inhibitor ( h ) or cultured under glutamine starvation (GS) ( i ) (n = 8 technical replicates representative from 2 independent experiments)