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Nonetheless, investigations into the anxiolytic properties of GLP-1RAs remain limited and further clinical trials are warranted to substantiate these preliminary findings.128 Impact of GLP-1RAs in Perioperative Period During the perioperative period, concerns have been raised regarding the use of GLP-1RAs and their potential association with an increased risk of bronchopulmonary aspiration due to delayed gastric emptying and retention of the gastric contents

The CT-996 drug belongs to the same family of GLP-1 hormone mimicking drugs as blockbuster injections like Ozempic, Wegovy, Mounjaro and Zepbound and Roche said the study indicates it is safe, well tolerated and has a similar profile of side effectsoften mild or moderate gastrointestinal issues like nausea and diarrheato oral GLP-1 drugs

The third approach aims to enhance endogenous GLP-1 production from intestinal L-cells