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Potential neurotransmitters: As an excitatory neurotransmitter, glutathione depolarizes neurons by acting as ionotropic receptors of its own which are separate from any other excitatory amino acid receptors

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Residues such as Lys209 and Lys248 are directly pointing towards the CoA molecule in the AlphaFold3 model, suggesting these might take over the acetyl groups from acetyl-CoA acting as nucleophiles upon binding of acetyl-CoA in a potential unproductive conformation before adopting its productive conformation (Figs

Notably, PCS patients retained core metabolic changes from the acute phase, including persistent elevations in glucose and reductions in glutamic acid