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Ferroptosis in rheumatoid arthritis RA is a multifactorial autoimmune disorder which characterized by the bone and cartilage destruction and synovial hyperplasia, thereby leading to joint pain, swelling and stiffness

In any case, lets add these discoveries to our master flowchart , which is just one article away from completion

Nature, 402 (6762), 656660

Notably, it has been found that silencing long noncoding RNAs (lncRNAs) nuclear paraspeckle assembly transcript 1 (NEAT1) promotes microRNA-129 and microRNA-204 inhibition of the MAPK/ERK signaling pathway and attenuates FLS synovitis in RA ( In addition to this, it is also important to alleviate the development of RA by down-regulating various cytokines