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Bethesda (MD): National Institute of Child Health and Human Development

Accordingly, several studies have been conducted to correlate the serum selenium status with the plasma GPx activity using rodent models as well as in human [29,30,31]

Despite inconclusive evidence on the link between IGF-1 and pediatric obesity, some studies have shown that increased circulating IGF-1 in pre-pubertal children with obesity may be associated with increased nutritional status or dysregulation of other hormones [70,71,72,73] Elevated IGF-1, along with hyperinsulinemia, increased leptin, thyroid hormones, and sex steroids, may contribute to accelerated skeletal maturation in children with obesity [74]