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Semaglutide is the right reference compound when the research question is about GLP-1R biology in isolation

The FDA approval process means these medications have been studied in large clinical trial populations, their manufacturing facilities are inspected by the FDA, and their labeling (including dosing instructions, warnings, and side effects) has been reviewed and approved by federal regulators

doi: 10.2337/db15-0374 19 ShenXXLiHLPanLHongJXiaoJHermansenKet al

Furthermore, the time-to-onset and severe outcomes of GLP-1 RAs-induced gastrointestinal AEs were also discussed, which was helpful for clinical practice and drug monitoring to a certain extent