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Key challenges in pulmonary drug administration include optimizing drug deposition, preventing rapid clearance, and ensuring formulation stability [214]

Theoretical interactions can be considered based on each drug's mechanism, though the following should be understood as hypothetical rather than established

GR + Myr, on average, doubled the bioavailability of SF (39.8 3.1%) compared to GR alone (18.6 3.1%), and increased the conversion rate in the first 8 h (25.4% 2.7%) compared to GR alone (8.0% 2.7) based on measurement of urinary metabolites

The reaction can also terminate in the presence of a chain-breaking anti-oxidant such as vitamin E (-tocopherol) (Halliwell & Gutteridge, 1984)