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Butyrate regulates colonic macrophages present in the lamina propria by inhibiting HDAC, and limits the generation of proinflammatory IL-12 and IL-6, as well as antimicrobial nitric oxide from lipopolysaccharide-stimulated macrophages (Chang et al., 2014

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They work by blocking the action of the DPP-4 enzyme and increasing the half-life of endogenous GLP-1 and GIP

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