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It is well established that intracellular iron ions can be reduced to ferrous ions, and the aggregation of ferrous ions can induce the generation of excessive ROS, which in turn induces cell death 19

if too much medication is taken, these stores are used up, potentially leading to oxidative stress in the liver

10.1016/J.REDOX.2021.101928 66 HongT.LeiG.ChenX.LiH.ZhangX.WuN.et al (2021b)

377 However, owing to the role of Notch in normal tissue homeostasis, on-target gastrointestinal toxicity has limited the clinical application of Notch signaling inhibitors