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The rate-limiting step in GSH synthesis is cysteine availability, regulated predominantly by the excitatory amino acid carrier 1 (EAAC1) transporter in neurons

Clinical studies and trials have indicated that therapies addressing the PYY system have the potential to reduce food intake, increase satiety, and promote weight loss

In this way, dermatologists and cosmetologists commonly promote glutathione for skin whitening, acne treatment, and anti-ageing regimens, driving up demand in clinics and wellness chains

210 The principles of Mendelian randomization, which leverages genetic variants influencing exposures (e.g., UA levels), can serve as a natural randomization method to study the causal effects of these exposures on disease outcomes