The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
Although copper peptide skin care products have existed for over a decade, theyve only recently gained notable popularity especially among those interested in clean and/or green beauty products (i.e., those that are nontoxic, have simple ingredients, are cruelty-free, vegan, sustainable, etc.).1 2 But theyve also stepped into the spotlight due to their numerous potential applications
For example, total leaf APX activities in Arabidopsis leaves are five to ten times greater than GR activities (e.g., Rahantaniana et al
It's popular in biohacking circles and often pops up in patient consults, but the FDA hasn't approved it for human therapy