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Development of antiobesity medication has not been easy, because of unexpected adverse events
In a Phase 2 trial, patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease were randomly assigned to given placebo, 25 or 50 mg OCA for 6 weeks, it shows increased insulin sensitivity (by 28.0% from baseline with 25 mg OCA (P=0.019) and 20.1% from baseline with 50 mg OCA (P=0.060)), and decreased biological indicators of liver inflammation and fibrosis (NCT00501592)
Poreba MA, Dong CX, Li SK, Stahl A, Miner JH, Brubaker PL
roseus was very good at killing several cancer cell lines in the lab (93)
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