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It is important to note that most side effects are mild, transient, and resolve with continued use or dosage adjustment

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Over decades of life, this progressive shortening leads to critically short telomeres, which trigger cellular senescence or apoptosis and contribute to the tissue dysfunction and organ decline associated with aging

Eur J Pharmacol 861:172593 Luetic K, Sucic M, Vlainic J, Halle ZB, Strinic D, Vidovic T et al (2017) Cyclophosphamide induced stomach and duodenal lesions as a NO-system disturbance in rats: L-NAME, L-arginine, stable gastric pentadecapeptide BPC 157