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Consistent with other reports regarding C-terminal truncations of its ortholog HNF4 61 , truncating the ligand-binding domain of NHR-49 altered its nucleocytoplasmic distribution, favoring a more pronounced nuclear localization under ad libitum feed conditions when compared to the full-length receptor (Fig

Clinical implications of estimated glomerular filtration rate dip following sodiumglucose cotransporter-2 inhibitor initiation on cardiovascular and kidney outcomes

Reduction in Mortality : The overall improvement in health markers and reduction in cardiovascular events contribute to a lower risk of death from various causes, including some cancers

Mitochondria play a critical role in regulating cell survival and apoptosis, and the respiratory chain is a principal structural and functional target of estrogenic activity