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Guidance from the American Diabetes Association (ADA), American Association of Clinical Endocrinology/The Obesity Society (AACE/TOS), American Gastroenterological Association (AGA), Endocrine Society, and the American Heart Association (AHA) notes that largescale trials of these agents have demonstrated sustained weight loss (roughly 10% to 20%), as well as improvements in glycemic control, blood pressure, lipid profiles, and other cardiometabolic risk factors

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