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The most recent ESC/EAS recommendations [9] and the position of the EAS experts [264] on HoFH did not significantly change the position on this issue, while recommending maintenance of pharmacological treatment at maximum tolerated doses [9, 264]

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That shortage exemption started closing in late 2024

doi: 10.1007/s00253-021-11406-8 103 GryaznovaMVKozarenkoONIvannikovaVMSmirnovaYDBurakovaIYAltukhovaOBet al