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This, in turn, triggers the HIF1A (hypoxia inducible factor 1 subunit alpha)-dependent Warburg effect and AIM2 (absent in melanoma 2)-dependent inflammasome activation, contributing to Kras G12D -induced pancreatic tumorigenesis [212]

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Unlike some other GHRPs, Ipamorelin exhibits a high degree of selectivity , meaning that its effects are largely confined to GH regulation without significant increases in ACTH (adrenocorticotropic hormone) or cortisol levels