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For beginners, it's advisable to start at the lower end (2040 mcg/day) to assess tolerance and minimize side effects (Siddle, Growth Hormone & IGF Research )

Patients whose dark circles are caused primarily by pigmentation rather than hollowing, or who have significant skin laxity or puffiness in the under-eye area, may not see the improvement they're hoping for, and in some cases filler can make those concerns more visible rather than less