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Those include: thyroid dysfunction anemia sleep apnea depression and anxiety Various medication side effects may play a role, too

Bei Y, Pan LL, Zhou Q, Zhao C, Xie Y, Wu C, Meng X, Gu H, Xu J, Zhou L, Sluijter JPG, Das S, Agerberth B, Sun J, Xiao J (2019) Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

For general wellness and maintenance, monthly is often enough

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