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No serious adverse events

T + TRO group, T injection (s.c.) + DMSO (i.p.) + TRO [troglitazone is a ligand of peroxisome proliferator-activated receptor (PPAR) as the GPX3 agonist, MedChemExpress, China] (15 mg/kg/day, i.g.)

At the end of therapeutic process on day 36, all the mice were sacrificed and their right hind ankle joint tissues were obtained

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