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While some earlier studies reported lower nocturnal serum or saliva levels of melatonin in depressed individuals, others reported no differences, or even higher levels compared to controls ( Though the immediate mechanisms of action of current antidepressants are well-understood, the delay in clinical outcome conveys the gap of knowledge on the complete pathways that ultimately determine the clinical response

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Treatment of patients with comorbid depression and diabetes with metformin and milnacipran