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Most people clear semaglutide about 5 weeks after their last dose (up to 57 weeks)

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Cagrilintide is a newer long-acting amylin analogue - in a phase 2 trial, once weekly cagrilintide resulted in a dose-dependent WL between 6 and 10.8% compared to 9% with liraglutide 3 mg and 3% with placebo [87]

Therefore, the association between an increased expression of ClpB and appetite suppression after administration of liraglutide was considered to be weak