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Yet, the changes in EEC numbers and activity observed seemed to be cell-type specific, since PYY expression remained unaltered, suggesting a selective induction of GLP-1 rather than a simple global upregulation of all EEC lineages and their products (154)

Also, it was unclear why the control patients didn't fill their GLP-1 prescriptions, leaving open the possibility of confounding

The more reliable signal is often your blood sugar: if your insulin isn't bringing your levels down the way it should, and you can't explain it otherwise, the insulin itself may be the problem

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