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188 KBs produced by liver metabolism not only promote mitochondrial respiration by increasing ATP production, but also reduce free radical production by increasing the efficiency of the mitochondrial respiratory chain complex (increasing NADH oxidation and inhibiting mitochondrial permeability conversion)

These agents enhance levels of biologically active GIP and GLP-1 by preventing their degradation by DPP-4, thereby stimulating glucose-dependent insulin secretion and improving glycemic control (Fig