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Some are approved to lower heart disease risk, and the FDA has cleared semaglutide to reduce the risk of heart attack, stroke, and cardiovascular death in adults with established heart disease and either obesity or overweight, a milestone first reported through the landmark SELECT trial summarized by Yale Medicine

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Works through different neural pathways than GLP-1, which is why combining cagrilintide with semaglutide (CagriSema) enhances weight loss beyond either alone

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