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For instance, the increased thirst some patients report can lead to more frequent urination, but studies show that this effect often lessens as the body adjusts, usually within the first 2 to 4 weeks

"Way back, when there really weren't too many other agents for obesity treatment," she'd prescribe more of it, she told Insider, but that was largely because "there wasn't anything else." But metformin's effects on weight loss are "kind of mild," compared to newer drugs like semaglutide, Apovian said, and persistent side effects like stomach cramps and diarrhea are a common concern among patients taking metformin

For them, supporting incretin hormones can sometimes help restore what their bodies once made more easily

These lifestyle changes, in conjunction with semaglutides benefits, can help create an optimal environment for conception