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38 This pain commonly presents as spontaneous burning sensations in the feet, and patients may also report positive sensory symptoms such as brush-evoked allodynia (pain from normally non-painful stimuli) and paresthesias, which are often accompanied by sensory loss, leading patients to describe the paradox of their feet being continuously painful yet insensate to touch

For some, symptoms settle within a few weeks as the body adapts

These are the different types of potential variations to look for: Homozygous variation You have two copies of the same MTHFR variation (either two variations on 677 or 2 variations on 1298)

doi: 10.1016/j.reumae.2025.501809