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Its been noted that folic acid fortification in food helps to lower the prevalence of neural tube defects by about 50% to 70%

This paradoxical improvement occurs because pain reduction outweighs any stimulatory effect on neurotransmitters

Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), vegans and vegetarians, people with pernicious anaemia or gastrointestinal disorders affecting absorption, and those taking certain medications such as metformin or proton pump inhibitors

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